DP can occur without alterations in γ (DP) but only when preceded by LTP that does not involve a change in γ (LTP)

<p><b>Copyright information:</b></p><p>Taken from "Bi-directional modulation of AMPA receptor unitary conductance by synaptic activity"</p><p>BMC Neuroscience 2004;5():44-44.</p><p>Published online 11 Nov 2004</p><p>PMCID:PMC535344.</p><p>Copyright © 2004 Lüthi et al; licensee BioMed Central Ltd.</p> (A) Plot of amplitude . time from a representative experiment. Black bar represents LTP pairing, grey bar DP pairing protocol. Throughout the figure, green represents baseline, red LTP and blue DP. (B) Current-variance relationship for baseline, LTP and DP (γ values for this cell (pS): baseline = 6.5, LTP = 6.7, DP = 6.0). (C) Mean EPSCs (average of all responses used for non-SFA) superimposed (left) and peak scaled (right). (D) Amplitude histogram (bin width = 2 pA; N = 151 for baseline, N = 211 for LTP, N = 513 for DP) for baseline, LTP and DP. Inset: 10 consecutive responses for baseline, LTP and DP

Bi-directional modification of AMPA receptor conductance (γ) during LTP (LTPγ) and DP (DP)

<p><b>Copyright information:</b></p><p>Taken from "Bi-directional modulation of AMPA receptor unitary conductance by synaptic activity"</p><p>BMC Neuroscience 2004;5():44-44.</p><p>Published online 11 Nov 2004</p><p>PMCID:PMC535344.</p><p>Copyright © 2004 Lüthi et al; licensee BioMed Central Ltd.</p> (A1,2) Plot of amplitude . time from two representative experiments. Black bar represents LTP pairing, grey bar DP pairing protocol. Throughout the figure, green represents baseline, red LTP and blue DP. (B1,2) Current-variance relationship for baseline, LTP and DP (γ values for the same cells (pS): cell 1:baseline = 2.2, LTP = 6.5, DP = 3.7; cell 2: baseline = 4.5, LTP = 7.4, DP = 3.2). For this figure and in Figure 3, lines are parabolic fits of the data (see Methods). (C1,2) Inset. Mean EPSCs (average of all responses used for non-SFA) superimposed (left) and peak scaled (right). Amplitude histograms (bin width = 2 pA; number of trials: cell 1: N = 130 for baseline, N = 245 for LTP, N = 533 for DP; cell 2: N = 150 for baseline, N = 267 for LTP, N = 337 for DP; frequency normalised to the data set with the smallest number of observations for baseline, LTP and DP)